Сообщений в теме: 3

[meds_]

New evidence puts into doubt the long-standing belief that a deficiency in serotonin—a chemical messenger in the brain—plays a central role in depression. In the journal ACS Chemical Neuroscience, scientists report that mice lacking the ability to make serotonin in their brains (and thus should have been "depressed" by conventional wisdom) did not show depression-like symptoms.

http://medicalxpress...depression.html

[2noel]

ЧТД

[meds_]

Я только вот этот момент не понял

While TPH2–/– mice as a group were not responsive to SSRIs, a subset responded to treatment with SSRIs in the same manner as wild-type controls with significant reductions in immobility time on the tail suspension test, indicative of antidepressant drug effects.

[2noel]

Я только вот этот момент не понял

While TPH2–/– mice as a group were not responsive to SSRIs, a subset responded to treatment with SSRIs in the same manner as wild-type controls with significant reductions in immobility time on the tail suspension test, indicative of antidepressant drug effects.

Несмотря на то что "в теории" СИОЗС на этих "мутантов" действовать не должно, по результатам теста их реакция на СИОЗС не отличалась от контрольной группы (качественно).
Т.е. (ИМХО) серотонин оказался совсем не при чем. Неожиданно.