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How the keto diet could one day treat autoimmune disorders by increasing anti-inflammatory compounds - Medical Xpress
Working with a mouse model of MS, the researchers found that mice who produced more of a particular ketone body, called β-hydroxybutyrate (βHB), had less severe disease.
The additional βHB also prompted the gut bacterium Lactobacillus murinus to produce a metabolite called indole lactic acid (ILA). This blocked the activation of T helper 17 immune cells, which are involved in MS and other autoimmune disorders.
"What was really exciting was finding that we could protect these mice from inflammatory disease just by putting them on a diet that we supplemented with these compounds," said Peter Turnbaugh, Ph.D., of the Benioff Center for Microbiome Medicine.