Наверное уже писалось, но все же. По поводу сочетания имао-B и
СИОЗС. А так же ограничений питания (опасность тираминового/сырного синдрома).
С сиозс сочетать можно. Диету соблюдать не надо, если нет проблем с давлением. Речь идёт о невысоких дозах (до 10мг селегилина).
http://forum.parkins...ect-rasagiline/
There have been thousands of patient experiences with SSRI's like Zoloft mixing with MAO-B's such as selegiline and rasagiline---it is safe. You can monitor for side effects with your doc but the literature strongly suggests this is ok to mix. MAO-A is dangerous to mix, but not MAO-B in most cases.
www.forum.parkinson.org/topic/21945-citalopram-selegiline-and-ropinirole-extended-release-oh-my/
As far as the interaction between the citalopram and selegine. According to the Idaho Drug Utilization Review, this interaction could happen with selegiline or rasagaline and ALL antidepressants: SSRI,s (which citalopram is), SNRI,s, Noradrenaline Reuptake Inhibitors, TCA's, RIMA,s, Tetracyclic Antidepressants, NaSSA's, MAOI's, and Melatonergic Antidepressants. It can also occur with Tramadol (synthetic opioid), Linezolid (antibiotic), Dextromethorphan (cough suppressant), Ginseng & St. John's Wort (herbal supplements), and Almotriptan, Eletriptan, Frovatriptan, Rizatriptan, Sumatriptan, Zolmitriptan (which are all known as "triptans). There are others but our major concern is Antidepressants.
The interaction can cause "Serotonin Syndrome." This is a very rare interaction, but can be very serious (up to death) if it occurs. In my 26 years of practice and speaking with hundreds of specialists, neurologists, and movement disorder specialists not one of them has ever had this interaction happen to any of their patients. The incidence of Serotonin Syndrome occurring is really not known. The latest figure I could find was from a May 2010 Article in American Family Physicians which stated that approximately 0.2% deaths were caused by Serotonin Syndrome in 2005 which was caused by the patients taking more than the prescribed dose (ie. overdosing) of an SSRI, not by an interaction. Signs of Serotonin Syndrome can be anxiety, delirium, restlessness, disorientation, sweating, rapid or irregular heart beat, high blood pressure vomiting, diarrhea, tremor, muscle rigidity, and hyperreflexia. The symptoms usually come on anywhere from 6 to 24 hours after taking more than the prescribed dose or an increase in dose.
www.forum.parkinson.org/topic/14366-avoiding-high-tyramine-foods/
It has been determined that no danger exists at the low doses of selegiline usually prescribed for PD, generally 10 mg per day. So, there is no tyramine restriction for those taking up to 10 mg per day of selegiline unless you have high blood pressure,
https://www.accessda...s019s020lbl.pdf
In theory, since MAO-A of the gut is not inhibited, patients treated with selegiline at a dose of 10 mg a day should be able to take medications containing pharmacologically active amines and consume tyramine-containing foods without risk of uncontrolled hypertension. Although rare, a few reports of hypertensive reactions have occurred in patients receiving Eldepryl at the recommended dose, with tyramine-containing foods. In addition, one case of hypertensive crisis has been reported in a patient taking the recommended dose of selegiline and a sympathomimetic medication, ephedrine. The pathophysiology of the ‘cheese reaction’ is complicated and, in addition to its ability to inhibit MAO-B selectively, selegiline’s relative freedom from this reaction has been attributed to an ability to prevent tyramine and other indirect acting sympathomimetics from displacing norepinephrine from adrenergic neurons. However, until the pathophysiology of the cheese reaction is more completely understood, it seems prudent to assume that selegiline can ordinarily only be used safely without dietary restrictions at doses where it presumably selectively inhibits MAO-B (e.g., 10 mg/day).