Сообщений в теме: 76

[CopperKettle]

# INTEGRATE: international guidelines for the algorithmic treatment of schizophrenia - The Lancet, 31 March 2025
 
I would translate this into Russian, but I’m translating slowly, it has been so since November 2020, that’s why I’m a food delivery courier now, not a translator anymore. I find it extremely hard to focus and plan actions.
 

Summary:
 
Schizophrenia is a mental illness involving multiple symptom domains and is often associated with substantial physical health comorbidities. Guidelines exist, but these tend to be country-specific and are often missing a concise yet comprehensive algorithmic approach. From May 1, 2023, to Jan 1, 2025, International Guidelines for Algorithmic Treatment (INTEGRATE) authors from all UN regions collaborated to develop a consensus guideline focused on the pharmacological treatment of schizophrenia. Following an umbrella review of the literature, input from expert workshops, a consensus survey, and lived experience focus groups, a consensus algorithmic guideline and associated digital tool were developed. Key recommendations include a focus on metabolic health from treatment initiation, timely assessment and management of non-response, symptom domain-specific interventions, mitigation of side-effects, and the prompt use of clozapine in cases of treatment resistance.

[MeanGo]

Apparently, it's rude to poke someone in the forehead and say "Skip Intro" when they start talking to you.

  I feel called out.

[CopperKettle]

Boosting the recycling process known as autophagy — impaired in the brain during prolonged stress — has the potential to restore normal neuronal activity and treat depression.

[CopperKettle]

[CopperKettle]

I spent 8 hours today just sitting at the keyboard and forcing myself to open a couple of letters and some personal messages. It's torture for me; I feel like my "Self" will shatter into pieces if there's something denigrating or reproachful inside a letter/message.

[CopperKettle]

I've started taking lactoferrin, because I read that in keratoconus patients, levels of it are decreased both in the blood and in the tear film - but I'm buying some Turkish brand, so I'm unsure whether the vial contains lactoferrin at all.

[MeanGo]

I spent 8 hours today just sitting at the keyboard and forcing myself to open a couple of letters and some personal messages. It's torture for me; I feel like my "Self" will shatter into pieces if there's something denigrating or reproachful inside a letter/message.

I know that it sounds lame, even patronizing, I don't want to be that and still - can you just get mad once and let them f%ck themselves if there is something ill-conceived. Chances of which are slim, even you know it on your harshest day. But still if there is - just let them %%ck off. I know I'm not helping...

[CopperKettle]

Have We Been Thinking About A.D.H.D. All Wrong? - By Paul Tough, in New York Times, 13 April 2025. 

A very interesting article, and it's quite easy to break the paywall - for instance, there was a browser applet titled Bypass Paywalls Clean for Firefox, and there must be numerous other ways. 

[ixthUA]

When i was a teen i read a book called 'Smell of a Woman' (in russian). Many years later i learned what 'smelly woman' means.

[CopperKettle]

When i was a teen i read a book called 'Smell of a Woman' (in russian). Many years later i learned what 'smelly woman' means.

 

Who was the author of the book?