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[CopperKettle]

Интересное из новостей. Пока на уровне мышей. 

 

How the keto diet could one day treat autoimmune disorders by increasing anti-inflammatory compounds - Medical Xpress 

 

Working with a mouse model of MS, the researchers found that mice who produced more of a particular ketone body, called β-hydroxybutyrate (βHB), had less severe disease.

 

The additional βHB also prompted the gut bacterium Lactobacillus murinus to produce a metabolite called indole lactic acid (ILA). This blocked the activation of T helper 17 immune cells, which are involved in MS and other autoimmune disorders.

 

"What was really exciting was finding that we could protect these mice from inflammatory disease just by putting them on a diet that we supplemented with these compounds," said Peter Turnbaugh, Ph.D., of the Benioff Center for Microbiome Medicine.

[CopperKettle]

"Кетоновые тела ускоряют выведение неправильно сконфигурированных белков в мышиных моделях процессов старения и болезни Альцгеймера"

 

Ketone esters help clear misfolded proteins in mouse model of aging and Alzheimer's disease

 

Ketone bodies, produced by the body to provide fuel during fasting, have roles in regulating cellular processes and aging mechanisms beyond energy production. Research at the Buck Institute shows that ketone bodies can best be understood as powerful signaling metabolites affecting brain function in aging and Alzheimer's disease.

 

A new study demonstrates that ketone bodies and similar metabolites have profound effects on the proteome and protein quality control in the brain.

 

Publishing in Cell Chemical Biology, Buck Institute scientists, working on mouse models of Alzheimer's disease and aging, and in the nematode C. elegans, reveal the ketone body β-hydroxybutyrate interacts directly with misfolded proteins, altering their solubility and structure so they can be cleared from the brain through the process of autophagy.

 

Научная публикация: b-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain, Cell Chemical Biology (2024). DOI: 10.1016/j.chembiol.2024.11.001. www.cell.com/cell-chemical-bio … 2451-9456(24)00459-8