Кто-нибудь знает как различаются эффекты антагонистов/обратных агонистов на 5НТ2С? Например агомелатин, тразодон и флуоксетин- антагонисты. Миртазапин, миансерин и нейролептики- обратные агонисты.
5-HT2C inverse agonists have been shown to inhibit mesoaccumbens dopamine outflow[90] attenuating the rewarding properties of various substances like morphine. This inhibition of dopamine may be stronger than thought as substances with 5-HT2C inverse agonist properties may have more activity to regulate dopamine neurotransmission than ones with competitive antagonism.[91] With its newly understood properties of 5-HT2C inverse agonism, it is being investigated and shown to lower drug seeking behaviour, conditioned place preference and the rewarding effects of substances such as methamphetamine in various human and animal studies.[74][92][93] It is also being investigated to help in substance abuse disorders with withdrawal effects and remission rates.[74][94] but some studies have shown mixed benefit.[74][95][96]
74. SB 206553, a putative 5-HT2C inverse agonist, attenuates methamphetamine-seeking in rats
90. In vivo evidence that constitutive activity of serotonin2C receptors in the medial prefrontal cortex participates in the control of dopamine release in the rat nucleus accumbens: differential effects of inverse agonist versus antagonist
91. Physiological and therapeutic relevance of constitutive activity of 5-HT 2A and 5-HT 2C receptors for the treatment of depression
92. Mirtazapine to reduce methamphetamine use: a randomized controlled trial
93. Mirtazapine treatment after conditioning with methamphetamine alters subsequent expression of place preference
94. Pharmacotherapy for methamphetamine dependence: a review of the pathophysiology of methamphetamine addiction and the theoretical basis and efficacy of pharmacotherapeutic interventions
95. Treatments for methamphetamine abuse: a literature review for the clinician
96. Pharmacotherapy of amphetamine-type stimulant dependence: An update
Вопрос очень интересный, однако... Заслуживает большого внимания.