«...Because the GMP food products were not supplemented with vitamins and minerals, all subjects were given a complete multivitamin with mineral supplement (Phlexy-Vits; Nutritia North America, Gaithersburg, MD) or a combination of Theragran M (Walgreen Co, Deerfield, IL) and Target-Mins (Country Life, Hauppauge, NY) during the GMP diet. Any subject consuming a formula or formulas that did not contain vitamins and minerals was given the same supplements provided for the GMP diet during the AA diet. Additional calcium was given, if needed, to meet Dietary Reference Intake (DRI) recommendations for age...»
«...The phenylalanine content for the commercial GMP was 0.4 g phenylalanine/100 g GMP with a protein content of 86.0 g/100 g GMP. This GMP was used for 3 subjects with a higher phenylalanine tolerance. For 9 subjects with a lower phenylalanine tolerance, the original stock of GMP was further purified to reduce the phenylalanine content to an average of 0.21 ± 0.01 g phenylalanine/100 g GMP with an average protein content of 75.0 ± 0.7 g/100 g GMP ( 25 ). Purification of the GMP decreased only the phenylalanine content; the proportion of the other AAs remained unchanged in the purified GMP compared with the commercial GMP...»
Что интересно: тирозина при GMP-диете требуется почти в два раза меньше, чем при гидролизатной...- «...The concentration of total AAs in plasma was significantly greater, and the concentration of BUN was significantly lower, with the GMP diet compared with the AA diet when measured 2.5 h after eating breakfast. This is consistent with slower absorption of AAs from an intact source of protein compared with synthetic AAs and higher insulin concentrations with ingestion of GMP...»
- «...Taken together, we conclude that it is prudent to supplement GMP with arginine for utilization in the PKU diet...»
- Ну и главная мысль (которая интуитивно тревожила меня в последнее время — и нашла своё документальное подтверждение):
«...Lifelong adherence to the PKU diet is very difficult, often resulting in *poor compliance and the neuropsychological consequences of hyperphenylalaninemia*...»
Поэтому, рассматриваемые выводы звучат как глоток надежды на адекватное терапевтическое решение в нашей ситуации.
«...This research shows a new, improved paradigm for the PKU diet through the use of palatable foods and beverages made with the intact, low-phenylalanine protein GMP instead of synthetic AAs. When supplemented with limiting indispensable AAs, GMP appears to be a safe and acceptable alternative to synthetic AAs as the primary protein source for nutritional management of PKU...»
Немного о "GMP" из сети:
1) http://www.innovatew...cropeptide.aspx
«...What is glycomacropeptide?
Glycomacropeptide (GMP) is a casein-derived whey peptide. This peptide is released by rennet during the manufacture of cheese or rennet casein. Purified GMP and GMP-rich whey protein concentrates are currently available in the U.S. market. This product is sometimes also called caseinmacropeptide (CMP).
Beneficial biological roles attributed to GMP or peptides derived from it include stimulation of cholecystokinin (a hormone regulating energy and food intake) release from intestinal cells, inhibition of platelet aggregation and support of beneficial intestinal bacteria (i.e., bifidobacteria). Studies have also shown that GMP may help to reduce dental caries.
GMP-rich whey protein concentrate is also a good source of branched-chain amino acids, which have been shown to promote lean muscle development.
Glycomacropeptides contain no aromatic amino acids and no phenylalanine. This makes GMP suitable for diets in the treatment of patients with phenylketonuria...»
2) http://www.maxs.com....611&pageID=2897
Glycomacropeptides (GMP)
«...a good quality Whey Protein Isolate supplement is highly recommended for the following reasons:
WPI is relatively easy to digest and so gets into your system fairly quickly
The amino acids profile is ideal for building muscle, better than all other proteins
WPI contains a range of bioactive protein fractions that stimulate muscle healing and growth as well as many other health promoting properties.
Good WPI formulas contain very low levels of carbs and fat – ideal for building and maintaining lean muscle...»