Сообщений в теме: 424

[Forvealis]

Pharmaceuticals | Free Full-Text | Psychotropic Drugs for the Management of Chronic Pain and Itch | HTML (mdpi.com)

 

With the help of extrinsic fluorescence quenching, it was demonstrated that venlafaxine is able to bind to the extracellular S1S2 domain of the NR1-1b subunit of the NMDA receptor, but not in clinically relevant concentrations. It was shown that venlafaxine takes part in maintaining NMDA receptors, and upregulating Grin2a and Grin2b expression. Venlafaxine treatment upregulated GRIA3 gene (glutamate receptor AMPA 3).

 

The anti-inflammatory effect of venlafaxine in the rat model of carrageenan-induced paw oedema was studied. It was shown that intraperitoneal and intracerebroventricular administration of the drug inhibited paw oedema, reduced myeloperoxidase activity, and decreased interleukin (IL)-1β and tumour necrosis factor (TNF)-α production.

 

Venlafaxine induced a dose-dependent antinociceptive effect, which was abolished by naloxone, norbinaltorphimine (κ-opioid receptor antagonist) and naltrindole (δ-opioid receptor antagonist), but not by beta-funaltrexamine (μ-opioid receptor antagonist). The authors suggested the involvement of κ- and δ-opioid mechanisms in an analgesic action of venlafaxine.

[Forvealis]

Гены "риска" шизофрении.

 

Dysbindin (dystrobrevin binding protein 1 or DTNBP1)

Neuregulin (NRG1)

DISC1 (disrupted in schizophrenia 1)

DAOA (D-amino acid oxidase activator; G72/G30)

DAAO (D-amino acid oxidase)

RGS4 (regulator of G protein signaling 4)

COMT (catechol-O-methyl-transferase)

CHRNA7 (α7-nicotinic cholinergic receptor)

GAD1 (glutamic acid decarboxylase 1)

GRM3 (mGluR3)

PPP3CC

PRODH2

AKT1

ErbB4

FEZ1

MUTED

MRDS1 (OFCC1)

BDNF (brain-derived neurotrophic factor)

Nur77

MAO-A (monoamine oxidase A)

Spinophylin

Calcyon

Tyrosine hydroxylase

Dopamine D2 receptor (D2R)

Dopamine D3 receptor (D3R)

[Forvealis]

https://pubmed.ncbi....h.gov/24781518/
Наверное отсюда и проблемы с памятью на высоких дозах венлафаксина.

[Forvealis]

Что то вообще 0 эффекта от бензоата. Ни побочек ни эффекта.

[MRDrama]

Ну как вам Бензоат натрия?

 

Увидел

Сообщение отредактировал MRDrama: 17 Март 2021 - 02:29

[Forvealis]

Что то вообще 0 эффекта от бензоата. Ни побочек ни эффекта.

Рабочая память и концентрация немного улучшились. Совсем немного, на уровне плацебо.

[Forvealis]

[Forvealis]

https://en.m.wikiped...e_growth_factor

NGF can indirectly stimulate the expression of adrenocorticotrophic hormone (ACTH) in the hypothalamic-pituitary-adrenal axis (HPA) by increasing vasopressin secretion. ACTH binds to the MC2 receptor in the zona fasciculata of the adrenal cortex, and stimulates secretion of the stress hormone cortisol.[12] This rapid increase of cortisol in the blood plasma can induce feelings of euphoria, which may explain the initial "rush" of falling in love.

[Forvealis]

https://www.omicsonl...1.php?aid=33887
Репорт по Amyloban 3399.

[Forvealis]

Апдейт по бензоату: здорово участилось чувство дежавю. Практически каждый час эта хрень случается.