Если у вас будет желание отпишитесь потом по моему гайду, что полезного там увидите. Будет интересно почитать.
Забавно.
while in comparison to SGAs clozapine was found to be less effective for negative symptoms than quetiapine and not significantly different to olanzapine and risperidone
the effect of clozapine on negative symptom scores was marginally inferior to olanzapine and comparable with a range of other FGAs
clozapine was modestly superior to other FGAs (chlorpromazine, haloperidol) and SGAs (olanzapine, risperidone, quetiapine, ziprasidone) in short-term studies (less than 3months, with a small effect size), but not in longerterm studies (over 3months)
Edit: Наверное я все таки вернусь на кветиапин.
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Of the 26 pharmacological add-on medications with non-clozapine antipsychotics, 12 were statistically significantly superior to controls.
Five of these(SSRIs, modafinil, any antidepressant, oestrogens, and another antipsychotic) had small effect sizes;
two (topiramate and minocycline) had medium effect sizes;
and five (testosterone, acetylcholinesterase inhibitors, lamotrigine, 5-HT3 receptor antagonists and SNRIs [a single study on duloxetine]) had large effect sizes.
Как то пробовал донепезил 2.5мг/сут. Неплохой эффект на когнитивку, особенно на память. Есть заметный синергизм с крепким кофе.
Насчет миноциклина. На forum.schizophrenia.com есть один пользователь который избавился от негативки за 3 дня на миноциклине. Что интересно, механизм мне не понятен. Из известного, миноциклин ингибирует микроглию, как то влияет на глутамат и anti-inflammatory. Но что из этого способно дать такой быстрый эффект мне не ясно. Знаю одного человека, который пробовал доксициклин от негативки, никакого эффекта на негативку не было.
Profile of minocycline and its potential in the treatment of schizophrenia (nih.gov)
reports have shown that minocycline is able to inhibit microglial activation via anti-inflammatory and antioxidant properties which are independent of its antimicrobial action.
Minocycline can also reduce the proliferation and activation of resting microglia.
glutamate-induced microglial activation occurred via the p38 mitogen-activated protein kinase pathway and that minocycline inhibited activation of this pathway in microglia, providing neuroprotection against excitotoxicity.
Получается что глутамат активирует микроглию. Выходит что саркозин и бензоат натрия, косвенно через активацию NMDA рецептора должны несколько успокаивать микроглию.
Minocycline affects a subtype of glutamate receptors known as GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors in neurons in vitro and in the CNS in vivo. Increased membrane localization of the GluR1 AMPA receptor improves glutamatergic activity and modulates neuroplasticity.
minocycline attenuated the reduction of dopamine transporters in monkeys treated with methamphetamine.
As an inhibitor of microglial activation, minocycline has anti-inflammatory, antioxidant, and antiapoptotic properties, and can modulate glutamate-induced excitotoxicity.
Всё упирается в глутамат и микроглию.
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The following treatment strategies were not statistically significant for negative symptoms: noradrenaline reuptake inhibitor antidepressants (NRI); lithium; NSAIDs; varenicline; azapirones; adenosine modulators;dehydroepiandrosterone (DHEA); noradrenergic and specific serotonergic antidepressant (NaSSA); monoamine oxidase-B (MAO- 
inhibitors; carbamazepine; serotonin antagonist and reuptake inhibitor (SARI) antidepressant (trazodone); oxytocin; pregnenolone; and glutamate NMDA receptor antagonism.
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Adjunctive administration of glycine, D-serine and D-cycloserine did not improve cognitive function, nor did D-serine when given in an attempt to boost cognitive remediation training.
While the medication had no effect on traditional neuropsychological tests, learning of the auditory discrimination task was significantly enhanced compared with placebo, and this correlated with reduction in negative symptoms.
Finally, L-carnosine is a dipeptide which increases the action of glutamate on NMDA receptors. An RCT of 75 patients showed improvement in a several measures of executive function and processing speed with small to medium effect sizes
Сообщение отредактировал Forvealis: 08 Март 2021 - 04:15