Хорошее обсуждение м-креазола можно прочитать здесь https://www.reddit.c...ted_about_3500/
В частности:
"Wait... You just proved yourself wrong. Did you look at this study you posted? It shows that toxicity will never be reached at the concentrations we're using Novolin R at. We're only using 0.1ml of the entire insulin preparation per spray. Spreading out the m-cresol in that spray over the entirety of our cerebral spinal fluid would equal a m-cresol concentration of around 0.002mg/ml. They didn't show any toxicity even at 0.5mg/ml. I just don't think it's a problem when it comes to intranasal insulin, but, like you, I am waiting for cleaner preparations. It is nice to be able to keep it at room temp, though.
People were also harping on insulin preparations' inclusion of zinc, saying that it may cause loss of smell, but, again, the concentrations just aren't there for it to be even almost a problem.
Edit: Okay so I took a second look at that study, and it's aim is to see if there might be any toxicity at an injection site over time from repeated injections in the same spot. They say the harm from m-cresol is caused by it creating an oxidative environment by reacting with phenols. This kind of environment, at low concentrations like with intranasal insulin, is easily taken care of by our body's antioxidants and wouldn't even cause stress.
Anyway, the concentrations they're studying wouldn't even happen during insulin injection. They study m-cresol at around 3mg/ml in these cultured cells for five minutes. There's no way an injection depot remains at that concentration for that long after injection, and even if it did, the immune response would shuttle resources into the site that a cell culture doesn't have access to.
You have to realize that, just because m-cresol is toxic if you inhale from a bucket of it, doesn't mean it's toxic at all levels. It seams that exercise could cause a similar oxidative environment concentration-wise than a spray of intranasal insulin would."